F.M. Abou-Tarboush
Inbred adult SWR/J and C57BL/6J mice as well as their reciprocal crosses were used to investigate the teratogenic and other possible effects of Aspirin on foetuses of females treated once each day from day 7 to 12 of pregnancy. The prenatal administration of the drug at a dose level of 400 mg/kg body weight or higher has significantly increased foetal mortality. However, there were no significant differences between two inbred strains in this respect, except at a dose level of 500 mg/kg, nor between the reciprocal crosses at all dose levels.
The prenatal administration of the drug has also increased exencephaly in foetuses of the C57 inbred strain at a dose level of 100 mg/kg or higher and in foetuses of C57 females x SWR male at a dose level of 500 mg/kg only. Foetuses of SWR inbred strain, as well as those of SWR females x C57 male appeared to be resistant to such inductive effects. Moreover, the prenatal administration of the drug at a dose level of 400 mg/kg or higher has significantly decreased foetal body weight in all mice used.