Mouse Strains Variations to Superovulation by Human Post Menopausal Gonadotrophins PDF

Keywords

gonadotrophin, hormones, mice

Abstract

Two commercially available gonadotrophic hormones: human post menopausal gonadotrophins (Pergonal, Serona, Italy) and human chorionic gonadotrophins (Profasi, Serona, Italy) have been used to test their superovulation capacity in females of three inbred mouse strains (Balb/c, CBA and C57BL/6). Females of the three strains have responded differently to the hormones and the dosage regime used. The best superovulation response was by Balb/c females to 10 IU of the hormones. Superovulation was also stimulated in CBA females by 10 IU of the hormones. The response has declined in females of both strains when the doses of the hormones were increased to 15 IU. However, superovulation in C57BL/6 females was only stimulated by the highest doses (15 IU) of the hormones used.