Author(s): Faisal M. Abou-Tarboush
Article publication date: 1994-04-01
Vol. 12 No. 1 (yearly), pp. 133-140.
158
Keywords
mice, gestation, foetuses
Abstract
Inbred normal adult CBA mice were used to investigate the possible teratogenic and other effects of Hiconcil (Amoxicillin) on foetuses of females treated intraperitoneally (ip) once each day from day 7 to 12 of pregnancy. The prenatal administration of Hiconcil at 500 or 650 mg.kg body weight resulted in both teratogenic and toxic effects on foetuses of treated mothers. Such effects comprised the development of abnormal hindlimbs and tails. However, the drug was safe to treated dams at all dose levels and at all times during gestation.