Effects of Indomethacin on Dams and Foetuses of CBA Mice PDF

Keywords

indomethacin, mice, foetuses

Abstract

Normal adult inbred CBA mice were used to investigate the teratogenic and other possible toxic effects of indomethacin on both dams and their foetuses. The dams were treated with various doses of the drug once each day from day 7 to day 12 of pregnancy. Treatments at 3, 4, or 6 mg/kg body weights significantly increased the foetal mortality rate and decreased the mean number of live foetuses. At a dose of 4 mg/kg body weight, the live foetal body weight was also significantly decreased. None of the doses used induced any foetal malformations, but higher ones (4 and 6 mg/kg body weight) were toxic to the dams.