Author(s): Faisal M. Abou-Tarboush
Article publication date: 1997-08-01
Vol. 15 No. 2 (yearly), pp. 437-445.
158
Keywords
mice, Hiconcil, gestation
Abstract
Normal adult inbred SWR/J mice were used in the investigation of the possible teratogenic and other effects of Hiconcil. Pregnant females were treated intraperitoneally (ip) daily from day 7 through day 12 of pregnancy. Hiconcil at a dose of 500 or 650 mg/kg body weight resulted in teratogenic effects in foetuses of treated mother including the development of abnormal hindlimbs, heads and tails. Moreover, some abnormally small foetuses were also obtained from treated mothers given these doses of the drug. However, the drug appeared safe to treated dams at all dose levels and throughout gestation.