Individual and Combined Effect of Chronic T-2 Toxin and Aflatoxin B1 Mycotoxins on Rat Liver and Kidney PDF

Keywords

rats, T-2 toxin. aflatoxin B1

Abstract

Twenty-eight male albino rats were divided into four groups, one group was injected intraperitoneally with T-2 toxin, a second group was injected with Aflatoxin B1, a third group was injected with a mixture of the two mycotoxins and one group was used as control. The weight of each rat was recorded at weekly intervals. At the end of the study, all rats were killed, blood samples were drawn to determine white blood cell count and packed cell volume. The liver, kidneys and other organs, which exhibited abnormalities, were weighed and processed for histopathological study. Aflatoxin B1, and the mixture of AFB1 and T-2 toxin caused a significant (p<0.005) drop in the average body weight of the rats after eight weeks of treatment. The highest PCV readings were recorded with rats injected with the mixture of AFB1 and T-2 toxin. Moreover, AFB1-treated rats and T-2 toxin-treated rats exhibited a significant (p = 0.02) decrease in the relative liver weight. The AFB1 and T-2 toxin mixture resulted in synergistic effects in most of the parameters of the study. The histopathological study confirmed the hepatotoxicity of AFB1. One case of immunoblastic lymphoma was observed in this study; this observation is thought to be the first report that suggested a possible relationship between mycotoxicosis and lymphoma.