Synthesis and Biological Activity of Some New Substituted Aminoacyl-Carbazole Derivatives. Part II. PDF

Keywords

Antimicrobial, Chemistry, Pharmacology

Abstract

3-Nitro-9-(N-phthalyl-and N-tosylaminoacyl) carbazoles (II-XI) have been synthesized by the action of 3-nitro-9H-carbazole (I) on N-phthalylor N-tosylamino acid in THF-Et)N medium using OCC.method. Treatment of the 3-nitro derivatives (II-XI) with Sn/HCI gave the corresponding 3-amino-9(N-phthalyl-or N-tosylaminoacyl) carbazoles (XII-XlX). Hydrazinolysis of the N-phthalyl-carbazole derivatives (In-VII) in ethanol gave the corresponding 3nitro-9-(aminoacyl) carbazoles (XX-XXIlI). Compounds (II-XI and XXI, XXII) were found to be active against some microorganisms.