The Degenerative Effect on Rabbit Implantation Sites by Indomethacin. II. Changes in Estrogen and Progesterone Levels as a Possible Cause for Indomethacin Antifertility Effect PDF

Keywords

Rabbits, Antifertility, progesterone

Abstract

The effect of Indomethacin (Jd) and prostaglandin F20c (PGF2oc ) alone or in combination on plasma estradiol-I7B and progesterone levels during days 5-9 of pregnancy in the rabbit was determined. Id treatment prevented the rise in plasma progesterone which was observed to occur in the non-treated animals after day 7. Treatment with PGF20c alone or together with Id resulted in a significant drop in plasma progesterone with subsequent disruption of the progesterone to estradiol ratio. Furthermore. there was only a limited success in reversing the antifertility effect of Id by PGF20c supplementation. The results of this experiment suggest that the antifertility effect of Id is at least partially related to its disruptive action on progesterone levels.