Synthesis of Some New Substituted Quinoline-Amino Acids and Dipeptide Derivatives and Studies of Their Antimicrobial Activities PDF

Keywords

chemistry, amino acids, antimicrobial activities

Abstract

The synthesis of 8-(N-phthalyl- or N- tosylaminoacyl or free aminoacyl or N- tosyldipeptidyl) aminoquin aldines (IV-XIX), 8-(N-phthalyl- or N-tosylaminoacyl) aminoquinoline- 2-carboxylie acid methyl esters (XX·XXVII) and their corresponding hydrazides (XXVIII-XXX) and some 2-carbonylamino acid methyl ester derivatives (XXXI-XXXIII) are described. 8-Nitroquinoline-2-carbonylamino acid methyl esters (XXXIV·XXXVII) and their corresponding hydrazides (XXXVIII-XLI) and some dipeptide methyl esters (XLII·XLV) have been synthesized by the carbodiimide and azide methods. Fourteen of various 2- and 8-substituted quinoline-amino acid derivatives are found to possess specific antimicrobial activities towards different microorganisms.