Effect of Chlorpromazine and Diazepam on the Metabolic Changes induced by Cold Stress in Rats PDF

Keywords

cold stress, diazepam, chlorpromazine

Abstract

The present investigation was undertaken to study the effects of acute and chronic cold stress on blood glucose, cholesterol, free fatty acids, triglycerides and phospholipids in rats and their modification with chlorpromazine and diazepam. Acute cold stress was produced by exposure of animals to +- 0.5 degree celsius for 4 hours. The antianxiety drugs diazepam (2 mg/kg body weight) and chlorpromazine (2 mg/kg body weight) were administered I.P. 30 minutes before the exposure of the animals to cold stress. Immediately after the exposure, the animals were sacrificed and blood samples were collected for biochemical analysis. In chronic studies, the rats were exposed to cold stress (4+- 0.5 degree Celsius) for 1 hour daily for six days. Diazepam (2 mg/kg) were given daily 30 minutes before the exposure to cold. On the sixth day, the animals were sacrificed following the exposure and blood was collected for biochemical analysis. The results of this study showed that both diazepam and chlorpromazine tend to normalize the changes in the values of the parameters representing the carbohydrate and lipid metabolism. However, diazepam was comparatively less effective as compared to chlorpromazine in this aspect.