Genotype and Allele Frequencies of MDR-l in Bahrain Population PDF

Keywords

MDR-J Gene, Human Population Genetics, Bahrain.

Abstract

The goal of this study was to determine the frequency ofthe single nucleotide polymorphism C3435T in MDR1 gene in the Bahraini population, and to compare them with the frequencies established in other ethnic populations. Genotyping was carried out on 184 unrelated Bahraini subjects. A PCRRFLP assay was applied for the determination of MDR-J variants. Results showed that 64 (34.8%) of the studied Bahraini subjects were homozygous for the CC genotype, 84 (45.7%) were heterozygous for the CT genotype and 36 (19.5%) were homozygous for the IT genotype. The frequencies of the wild-type allele 3435C and the 3435T variant in the MDR-J Gene were found to be 0.58 and 0.42, respectively. In conclusion, Bahrainis resemble other Arabs with regard to allelic frequencies of the MDR-J variants. The results ofMDR-1 genotyping in Bahraini individuals may provide a framework for more rational use of drugs that are substrates for MDR-J. The data obtained may be useful in clinical pharmacogenetic investigations and epidemiological studies of the MDR-J gene variation.