Author(s): A. El Mougith, J.L. Fonvieille, J-M. Touze-Soulet, R. Dargent and Ch. Montant
Article publication date: 1986-06-01
Vol. 4 No. 1 (yearly), pp. 259-267.
120
Keywords
lipid, fungal, Mucor mucedo
Abstract
Cytochalasins are a group of fungal metabolites which inhibit a variety of cellular functions. Cytochalasin A (CA) is the most effective against fungi. After the screening for the effect of CA, Mucor mucedo was chosen to study the influence of this drug on hyphal differentiation and metabolism. The effect of CA on the lipid composition of growing hyphae was studied. The reduction of total mycelial lipids was 31.33% in two days and 24.14% in four days. The enhancement in phospholipid content was 3.14% and 31.14% in two and four days-old mycelium respectively, while the neutral lipids were reduced by the same values. CA induced some modification in the proportions of: fatty acids; neutral lipids (sterol; diacylglycerides; free fatty acids; triacylglycerides; sterols esters) and in the constituents of phospholipids [decrease of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) and increase of phosphatidylglycerol (PG)].