Serum Lecithin Cholesterol Acyltransferase Activity, HDL, and HDL, Amounts and Composition in Hypertensive Patients with Various High Atherosclerosis Risk PDF

Keywords

Atherosclerosis, risk factors, LCAT, HDL, HDL, 207 Serum Lecithin Cholesterol Acyltransferase Activity, HDL, and HDL

Abstract

The effect of high risk atherosclerosis was investigated on HDL, HDL, amounts and composition and Lecithin cholesterol acyltransferase (LCAT) activity in 448 patients (M/W, 223/225) with high risk atherosclerosis. The mean age was 53 4 years and the mean BMI was 26 2. The subjects were divided into eight groups (GI- GVIII) and compared with 51 controls (M/W, 25/26) with a mean age of 50 + 6 and BMI of 22 + 1. Triacylglycerols concentrations were 1.8- to 2.3-fold higher in all groups than in the controls. Total cholesterol concentrations were 1.3- to 1.6-fold higher in all high risk atherosclerosis patients, than in controls. LCAT activity was decreased in patients of GI (P<0.05). GII, GIII, GIV (P<0.01), GV, GVI, GVII and GVIII (P<0.001), compared with the control values. A negative correlation was noted between LCAT activity and HDL,-PL in atherosclerosis high risk patients (r= -0.69. P<0.01), a positive correlation between LCAT and HDL - CE (r= 0.55, P<0.01). An inverse relationship was found between LCAT activity and hypertriglyceridemia (r= -0.76, P<0.01) and between hypertriglyceridemia and HDL-CE (r=-0.63, P<0.01). A negative correlation was also reported between total serum cholesterol and HDL2-CE (r= -0.87, P<0.01). A positive correlation was reported between total serum cholesterol and serum triacylglycerols (r=0.99, P<0.01). The degree of alteration in the HDL and HDL, amounts and composition, as well as LCAT activity decrease were proportional to the number of risk factors. According to the presence of one or several atherosclerosis risk factors, the alterations in HDL, and HDL, amounts and composition contribute to reduced efficacy of reverse cholesterol transport, which is another risk factor for cardiovascular disease.