Synthesis, Characterization, and Antibacterial Activity of Some 5-aryl-1, 3-Diphenyl-4, 5-dihydro-1H-Pyrazoles PDF

Keywords

acetophenone, chalcones, arylaldehyde, pyrazoles, Pyrazoline, TG, DTA, thermal analysis, antibacterial activity

Abstract

The condensation of acetophenone (I) with arylaldehyde (II) was investigated, and the resulting chalcones 2-Arylidene 1-Acetophenone (III) were reacted with phenyl hydrazine and acetic acid to produce substituted 5-aryl-1, 3-diphenyl-4. 5-dihydro-1H-pyrazoles (IV). The structures of all products were studied by 'H-NMR, IR, thermal and elemental analysis. Thermo gravimetric (TG) and differential thermal analysis (DTA) was applied to investigate the thermal behavior and structure of the synthesized compounds 2-Pyrazolines (IV) exhibited moderate activity against Streptococcus faecalis ATCC 19433, Klebsiella pneumoniae ATCC 13883, Proteus vulgaris ATCC 25922. Shigella sonnei ATCC 25931, and Peseudom oaeruginosa ATCC 27853