Effect of Nigella Sativa on Blood Lipids in Normal Rats PDF

Keywords

Nigella Sativa, Blood lipids, Rats, Saudi Arabia

Abstract

We have studied the effect of Nigella Sativa seeds on the blood levels of cholesterol, triglycerides, HDL and LDL in white albino rats. A total of 200 rats, 150 experimental and 50 controls, were included in the study. Six doses of N. Sativa were used (50, 100, 200, 300, 400 and 500 mg/day/200g rat). Each dose was given for five durations: 1, 4, 7. 10, and 14 days. Generally all doses of N. Sativa produced significant reduction in the blood level of all parameters studied. There was no linear dose or time dependent effect of N. Sativa on these parameters. The effect of N Sativa started after 4 days and continued, with some swings, for the rest , of the duration. The effective dose of N Sativa seemed to lie between 100-400mg. It is concluded that N. Saliva has a hypocholesterolemic effect. Therefore, we recommend further research on the effect of N. Sativa in related diseases in humans and animals.