Author(s): A. Essawy, A.M. El-Gendy, M. El-Safty and S.A. Said
Article publication date: 1988-08-01
Vol. 6 No. 2 (yearly), pp. 181-189.
140
Keywords
reactions, chemistry, methylene
Abstract
3-Benzyl-5-(Carboxy or Carbethoxy)- methylthio-1,2,4-triazole (1a &b) have been prepared. (1a) was cyclized to give 6-benzylthiazole(3.2-b)-s-triazol-3(2H)-one(II). The reaction of the active methylene of compound (II) with aromatic aldehydes and/or arene diazonium salts gave the corresponding 2-arylidene-6-benzylthiazolo(3,2-b)-s-triazol-3(2H)-one derivatives (III a-c) and 2,3-dihydro-6-benzylthiazolo-(3,2-b)-s-triazol-2,3-dione-2-arylhydrazone (IV a-c). Also, hydrazinolysis of compound (Ib) and its condensation with aromatic aldehydes have been studied and gave (V a & b) and (VI a & b) respectively