Author(s): FA Zaied
Article publication date: 2001-04-01
Vol. 19 No. 1 (yearly), pp. 12-18.
141
Keywords
Cisplatin, Sperm morphology, Rattus orvegicus
Abstract
The mutagenicity and genotoxicity of chemotherapeutic drugs used as chemical antibiotics in most tumours as anticarcinogenic agents were studied. Cis-diamminedichloroplatinum (cisplatin) is a commonly used chemotherapeutic agent in the treatment of ovarian, testicular and bladder cancer. It is used intravenously, intra arterially and intraperitoneally. Group I adult male rats were injected with a single dose at a level of 1/2 LD50 (16 mg/kg body weight (a half carcinogenic dose). Group II rats were treated with 9 mg/kg body weight (recommended dose) intraperitoneally injected. The abnormally shaped sperms were recorded after 1, 2, 3, 4 and 5 weeks post-injection. The frequency of abnormally shaped sperms was noted within the first three weeks post-injection, and highly significant abnormalities were recorded at the end of second week (181.4 ± 24.9) and (145 .1 ± 28.6) in Groups I and II, respectively. Recovery from the genotoxicity of cisplatin was achieved at the end of the 5th week