Effect of Solvent on the Product Formation in the Reaction of Hydrazine's with β-Aroyl-α- [4(1, 3-Disubstituted- 2- Pyrazolin-5 -One)] Propionic Acids PDF

Keywords

β-Aroyl-α- [4(1, 3-Disubstituted- 2- Pyrazolin-5 -One)] Propionic Acids, acetic acid, hydrazine

Abstract

The reaction of β-aroyl-α- [4(1, 3-disubstituted- 2- pyrazolin-5 -one)] propionic acids 1 with hydrazines in acetic acid afforded the unexpected 6- aryl-pyridazin-3-ones-3 instead of the expected 4-pyrazolinonyl pyridazinones through the fission of the 1, 3-disubstituted-2- pyrazolin -5-one. A probable mechanism has been proposed. Reactions of 6-aryl-pyridazin-3-ones with dimethylsulphate, diethyl sulphate, ethyl bromoacetate, phosphorous oxychloride and phosphorus pentasulphide have also been described.